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Psilocybin: A Potential Solution for Terminally Ill Patients? Here’s Why Many Canadians Support This Approach

By April 16, 2024July 30th, 2025Shrooms Online

People grappling with terminal diseases often undergo significant emotional distress, including depression, anxiety, existential dread, and a feeling of lost purpose, which amplifies the difficulty of their circumstances.

Though traditional treatments such as counselling and cognitive-behavioural therapy (CBT) can provide relief, they aren’t universally effective. Consequently, researchers are venturing into alternative, avant-garde methods of end-of-life care.

There is an emergent body of evidence suggesting that psychedelic therapy could potentially alleviate existential discomfort in patients with incurable conditions. According to a review in Neuropsychopharmacol Biol Psychiatry, psychedelics may ease depression and anxiety symptoms, improve life quality, and reduce death-related fears in individuals dealing with life-threatening diseases.

In a bid to further investigate the efficacy of psilocybin mushrooms, it is not uncommon for Canadians to buy shrooms online for research purposes.

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Psilocybin’s Impact on the Brain

The National Institutes of Health characterise psychedelics originating from mushrooms as potent substances that can alter cognition by interacting with the brain’s serotonin circuits, thus impacting mood and perception. 

Let’s delve into what various studies have discovered:

ResearchersDiscoveries
Department of Psychiatry and Behavioral Sciences, University of TexasPsychedelics such as psilocybin impact serotonin 2A receptors which regulate emotions and perception. 
A study from Mental Health NewsPsilocybin, a naturally occurring hallucinogenic compound present in over 200 fungi species, could potentially rewire the brains of those with depression, potentially paving the way for a cure.
Researchers from UC San Francisco and Imperial College LondonPsilocybin enhances connections between various brain regions in depressed individuals, possibly aiding them in overcoming excessive self-focused thinking and rumination.
A randomized, double-blind trial by John Hopkins University High dosage of psilocybin significantly reduced depression, anxiety, and death anxiety while improving life quality, sense of life’s meaning, and optimism.
Clinical trial from New York University Between 60% and 80% of participants reported a reduction in anxiety.
Psilocybin therapy has been observed to contribute to decreases in anxiety and depression, resulting in reduced existential distress. The therapeutic effects were found to be associated with the psychedelic experience triggered by psilocybin.

Exploratory Study

Researchers from the UCSF Weill Institute for Neurosciences conducted two studies, involving 60 participants who underwent fMRI brain scans, to provide supporting evidence for this.

Methodology

  • First Study. Participants, all of whom were battling treatment-resistant depression, were given psilocybin.
  • Second Study. Participants suffering from less severe depression were kept in the dark about whether they received psilocybin or an escitalopram placebo. All participants also received the same psychotherapy.

Brain scans were captured before and after the treatment to assess the effects.

Results

  • Psilocybin treatment reduced connections within brain areas related to depression, like the default mode, salience, and executive networks, and increased connections to less integrated brain regions.
  • It mitigated emotional avoidance effects and led to significant improvements in cognitive functioning.

Psilocybin’s effect on brain rewiring was sustained for up to three weeks after the second dose. Therefore, psilocybin offers a promising alternative treatment for depression by reshaping the brain and reducing entrenched negative thought patterns related to the illness. This outcome suggests that psilocybin operates differently to conventional antidepressants.

Psilocybin Therapy – A Promising Treatment Approach

Psilocybin therapy involves the controlled use of psilocybin in a therapeutic setting, often in conjunction with psychological support. This approach is increasingly being recognized for its capability to address treatment-resistant depression, anxiety, and existential distress in terminally ill patients.

Researchers from Université Laval’s Faculty of Pharmacy, McGill University, Université de Montréal, and UQAR recently conducted a survey to gauge public opinion on the medical use of psilocybin for end-of-life care. According to the study published in Palliative Medicine, almost 4

One in five Canadians support the use of psilocybin as a means to soothe end-of-life existential distress.

Lead researcher Michel Dorval noted that studies have shown psilocybin, when used in combination with psychotherapy, can provide quick, substantial, and long-lasting relief for individuals grappling with advanced cancer. It’s important to highlight that psilocybin therapy can elicit a deep sense of understanding and relief that may endure for up to six months.

In addition, the survey indicates that those who have experience with palliative care or prior psilocybin use demonstrated more significant support. Dorval suggested that personal experiences with end-of-life distress may contribute to this receptivity towards innovative approaches.

Despite the prevalent prejudices against psychedelic drugs, the research shows a growing acceptance of psilocybin therapy in Canada, particularly in palliative and end-of-life care contexts. The authors predict these findings will improve the availability of this groundbreaking therapy.

Further Benefits of Psilocybin Therapy

1. Treatment for Alcohol Use Disorder

In a double-blind, randomized trial of 93 participants, published in JAMA Psychiatry in August 2022, it was found that combining psilocybin with psychotherapy resulted in significantly fewer days of heavy drinking over approximately eight months compared to a control group undergoing placebo therapy. The group that was administered psilocybin also drank less alcohol on the days they did consume it.

2. Aid in Smoking Cessation

Quitting smoking is notoriously difficult, but a small pilot study by Johns Hopkins University researchers, published in The American Journal of Drug and Alcohol Abuse in January 2017, suggested that psilocybin, in conjunction with cognitive behavioural therapy (CBT), enabled 10 out of 15 participants to remain smoke-free for a year. A subsequent study implied that the psychedelic experience could potentially help reshape a smoker’s identity, thus fostering long-term abstinence.

3. Therapeutic Approach for Anorexia

Emerging research indicates that psilocybin might be helpful for individuals struggling with anorexia. A preliminary study published in Biological Psychiatry in May 2022 reported significant reductions in symptoms of eating disorders and anxiety in adults with anorexia who underwent psilocybin-assisted psychotherapy.

4. Alleviating End-of-life Anxiety

Living with Terminal Illness

Patients grappling with terminal diseases often suffer from anxiety and depression. Emerging evidence suggests that psilocybin therapy can help ease these symptoms significantly. Studies have demonstrated noteworthy reductions in depression and anxiety among patients diagnosed with life-threatening cancer who have received psilocybin therapy.

What to Expect from Psilocybin Therapy?

Psilocybin therapy offers the potential for remarkable healing outcomes in a relatively short time, potentially providing enduring benefits. Each session is customized to the individual’s needs and follows specific clinic or trial protocols. 

PhaseDescriptionDuration
BeforeThe initial sessions aim to address any fears and set treatment goals, facilitated by a therapist. The goal is to build a solid rapport and a safe environment.1 to 6 hours
DuringThe participant ingests a dose of psilocybin in a relaxed environment, lying down, wearing an eye mask, listening to a chosen playlist, with a therapist present.5 to 8 hours
AfterFollow-up sessions offer an opportunity to reflect on the experience with the therapist, aiding the integration of the insights into daily life.Several sessions over an extended period

Guidelines for Approaching Psilocybin Therapy

  • Explore clinics where psilocybin is legal and be prepared to join a waiting list if necessary.
  • Choose a clinic that administers psilocybin therapy under the supervision of a therapist or a professional guide for an optimally therapeutic experience.
  • Interview potential therapists to learn about their qualifications, experience, therapeutic approaches, and proficiency in dealing with mental health conditions.
  • Disclose your actual motives for seeking treatment, mental health status, medical history, and family mental health background.
  • Consider therapists who specialize in your specific mental health condition and consult organizations like the Psilocybin Assisted Therapy Association (PATA) for guidance and education.
  • Provide a detailed account of your medical and mental health history, especially if there’s a family history of schizophrenia or psychosis.
  • Discuss your decision to undertake psilocybin therapy with your current mental health provider and ask if they are open to collaborating with your psilocybin therapy team.
  • Discuss the dosage, protocol, and the possibility of starting with a low dose and gradually increasing it with your therapist.
Begin your journey with psilocybin therapy cautiously, especially if you’re a novice. We recommend starting with smaller doses for safety under the supervision of your psilocybin therapist.

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Frequently Asked Questions

Who is suitable for psilocybin therapy?

If you are battling depression, anorexia, alcohol addiction, trying to quit smoking, or coping with a terminal disease, psilocybin therapy might be a viable option for you. 

However, if you have a history of schizophrenia or psychosis, or these conditions are common in your family, hallucinogenic substances like psilocybin could exacerbate your symptoms. Likewise, individuals with bipolar disorder and borderline personality disorder are generally advised against it.

What is the usual dosage for psilocybin therapy?

The dosage typically fluctuates, often starting with smaller amounts in a therapeutic environment and adjusting based on the individual’s responses. Clinical trials have shown that a single 25-milligram dose of synthetic psilocybin, combined with psychological support, led to a reduction in depression scores among individuals with treatment-resistant depression.

Can psilocybin be used to treat PTSD?

This is a rapidly expanding research area. However, the studies on MDMA, an unconventional psychedelic with stimulant properties used alongside psychotherapy for PTSD treatment, are more advanced. Research on this psychedelic has reached phase 3 clinical trials, and it is expected that MDMA may receive approval for PTSD treatment this year.

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